CONTENTS

List of Abbreviations

Chapter 1 Raison d'être and Overview

Chapter 2 General Introduction

2.1 History of Cannabis Use

2.2 Prevalence of Cannabis Use

2.3 The Cannabis Plant and its Preparations

2.4 Chemistry and Pharmacology

2.5 Effects of Cannabis Use

2.5.1 Acute Effects

2.5.2 Factors influencing the Drug's Acute Effects

2.5.3 Chronic Effects

2.5.4 Tolerance and Dependence

2.5.5 Therapeutic Applications

2.6 Summary and Conclusions

Chapter 3 Cannabis and Driving

3.1    Epidemiological Studies

3.2 Laboratory Studies of Skills Related to Driving

3.3    Driving Simulator Studies

3.4 Actual Driving Studies

3.5 General Conclusion

Chapter 4 General Methods

4.1 Description of a 4-Study Program

4.2 Compliance with Ethical and Legal Standards

4.3    Subject Recruiting

4.4 Marijuana Cigarettes and Smoking Procedures

4.5 Screening for the Presence of Other Illicit Drugs and Alcohol

4.6 Blood Sampling and Quantitative Analyses

Chapter 5 Laboratory Study to Select THC Doses

5.1 Introduction

5.2 Methods

5.3    Results

5.4 Discussion

Chapter 6 Marijuana and Driving on a Restricted Highway

6.1    Introduction

6.2 Methods

6.3 Results

6.4 Discussion

Chapter 7 Marijuana and Driving on a Normal Highway in Traffic

7.1    Introduction

7.2 Methods

7.3    Results

7.4 Discussion

Chapter 8 Marijuana, Alcohol and Urban City Driving

8.1    Introduction

8.2 Methods

8.3    Results

8.4 Discussion

Chapter 9 General Discussion, Conclusions and Recommendations

9.1 Introduction

9.2 Tiic Doses

9.3 The Driving Tests

9.4 Effects of THC on Driving Performance

9.4.1 Results of Present Studies

9.4.2 Drug Plasma Concentrations and Driving Performance

9.4.3 Cannabis versus Alcohol and Other Psychotropic Drugs

9.4.4 Why are THC's Effects on Driving Performance relatively Small?

9.4.5 Concluding Remarks

9.5 Summary of Conclusions

9.6 Summary of Recommendations

Summary

© digitalized by drugtext foundation