Drug Abuse

4.   LSD

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Albert Hofmann's discovery of LSD in 1943 may have begun a new age in the exploration of the human mind, but it took six years for word to reach America. Even after Hofmann and his coworkers in Switzerland published their work in a 1947 article, no one in the United States seemed to notice. Then in 1949, a famous Viennese doctor named Otto Kauders traveled to the United States in search of research funds. He gave a conference at Boston Psychopathic Hospital,[1] a pioneering mental-health institution affiliated with Harvard Medical School, and he spoke about a new experimental drug called d-lysergic acid diethylamide. Milton Greenblatt, the hospital's research director, vividly recalls Kauders' description of how an infinitesimally small dose had rendered Dr. Hofmann temporarily "crazy." "We were very interested in anything that could make someone schizophrenic," says Greenblatt. If the drug really did induce psychosis for a short time, the Boston doctors reasoned, an antidote—which they hoped to find—might cure schizophrenia. It would take many years of research to show that LSD did not, in fact, produce a "model psychosis," but to the Boston doctors in 1949, the drug showed incredible promise. Max Rinkel, a neuropsychiatrist and refugee from Hitler's Germany, was so intrigued by Kauders' presentation that he quickly contacted Sandoz, the huge Swiss pharmaceutical firm where Albert Hofmann worked. Sandoz officials arranged to ship some LSD across the Atlantic.
The first American trip followed. The subject was Robert Hyde, a Vermont-born psychiatrist who was Boston Psychopathic's number-two man. A bold, innovative sort, Hyde took it for granted that there would be no testing program until he tried the drug. With Rinkel and the hospital's senior physician, H. Jackson DeShon looking on, Hyde drank a glass of water with 100 micrograms of LSD in it—less than half Hofmann's dose, but still a hefty jolt. DeShon describes Hyde's reaction as "nothing very startling." The perpetually active Hyde insisted on making his normal hospital rounds while his colleagues tagged along. Rinkel later told a scientific conference that Hyde became "quite paranoiac, saying that we had not given him anything. He also berated us and said the company had cheated us, given us plain water. That was not Dr. Hyde's normal behavior; he is a very pleasant man." Hyde's first experience was hardly as dramatic as Albert Hofmann's, but then the Boston psychiatrist had not, like Hofmann, set off on a voyage into the complete unknown. For better or worse, LSD had come to America in 1949 and had embarked on a strange trip of its own. Academic researchers would study it in search of knowledge that would benefit all mankind. Intelligence agencies, particularly the CIA, would subsidize and shape the form of much of this work to learn how the drug could be used to break the will of enemy agents, unlock secrets in the minds of trained spies, and otherwise manipulate human behavior. These two strains—of helping people and of controlling them—would coexist rather comfortably through the 1950s. Then, in the 1960s, LSD would escape from the closed world of scholar and spy, and it would play a major role in causing a cultural upheaval that would have an impact both on global politics and on intimate personal beliefs. The trip would wind up—to borrow some hyperbole from the musical Hair— with "the youth of America on LSD."

The counterculture generation was not yet out of the nursery, however, when Bob Hyde went tripping: Hyde himself would not become a secret CIA consultant for several years. The CIA and the military intelligence agencies were just setting out on their quest for drugs and other exotic methods to take possession of people's minds. The ancient desire to control enemies through magical spells and potions had come alive again, and several offices within the CIA competed to become the head controllers. Men from the Office of Security's ARTICHOKE program were struggling—as had OSS before them—to find a truth drug or hypnotic method that would aid in interrogation. Concurrently, the Technical Services Staff (TSS) was investigating in much greater depth the whole area of applying chemical and biological warfare (CBW) to covert operations. TSS was the lineal descendent of Stanley Lovell's Research and Development unit in OSS, and its officials kept alive much of the excitement and urgency of the World War II days when Lovell had tried to bring out the Peck's Bad Boy in American scientists. Specialists from TSS furnished backup equipment for secret operations: false papers, bugs, taps, suicide pills, explosive seashells, transmitters hidden in false teeth, cameras in tobacco pouches, invisible inks, and the like. In later years, these gadget wizards from TSS would become known for supplying some of history's more ludicrous landmarks, such as Howard Hunt's ill-fitting red wig; but in the early days of the CIA, they gave promise of transforming the spy world.
Within TSS, there existed a Chemical Division with functions that few others—even in TSS—knew about. These had to do with using chemicals (and germs) against specific people. From 1951 to 1956, the years when the CIA's interest in LSD peaked, Sidney Gottlieb, a native of the Bronx with a Ph.D. in chemistry from Cal Tech, headed this division. (And for most of the years until 1973, he would oversee TSS's behavioral programs from one job or another.) Only 33 years old when he took over the Chemical Division, Gottlieb had managed to overcome a pronounced stammer and a clubfoot to rise through Agency ranks. Described by several acquaintances as a "compensator," Gottlieb prided himself on his ability, despite his obvious handicaps, to pursue his cherished hobby, folk dancing. On returning from secret missions overseas, he invariably brought back a new step that he would dance with surprising grace. He could call out instructions for the most complicated dances without a break in his voice, infecting others with enthusiasm. A man of unorthodox tastes, Gottlieb lived in a former slave cabin that he had remodeled himself—with his wife, the daughter of Presbyterian missionaries in India, and his four children. Each morning, he rose at 5:30 to milk the goats he kept on his 15 acres outside Washington. The Gottliebs drank only goat's milk, and they made their own cheese. They also raised Christmas trees which they sold to the outside world. Greatly respected by his former colleagues, Gottlieb, who refused to be interviewed for this book, is described as a humanist, a man of intellectual humility and strength, willing to carry out, as one ex-associate puts it, "the tough things that had to be done." This associate fondly recalls, "When you watched him, you gained more and more respect because he was willing to work so hard to get an idea across. He left himself totally exposed. It was more important for us to get the idea than for him not to stutter." One idea he got across was that the Agency should investigate the potential use of the obscure new drug, LSD, as a spy weapon.
At the top ranks of the Clandestine Services (officially called the Directorate of Operations but popularly known as the "dirty tricks department"), Sid Gottlieb had a champion who appreciated his qualities, Richard Helms. For two decades, Gottlieb would move into progressively higher positions in the wake of Helms' climb to the highest position in the Agency. Helms, the tall, smooth "preppie," apparently liked the way the Jewish chemist, who had started out at Manhattan's City College, could thread his way through complicated technical problems and make them understandable to nonscientists. Gottlieb was loyal and he followed orders. Although many people lay in the chain of command between the two men, Helms preferred to avoid bureaucratic niceties by dealing directly with Gottlieb.
On April 3, 1953, Helms proposed to Director Allen Dulles that the CIA set up a program under Gottlieb for "covert use of biological and chemical materials." Helms made clear that the Agency could use these methods in "present and future clandestine operations" and then added, "Aside from the offensive potential, the development of a comprehensive capability in this field . . . gives us a thorough knowledge of the enemy's theoretical potential, thus enabling us to defend ourselves against a foe who might not be as restrained in the use of these techniques as we are." Once again, as it would throughout the history of the behavioral programs, defense justified offense. Ray Cline, often a bureaucratic rival of Helms, notes the spirit in which the future Director pushed this program: "Helms fancied himself a pretty tough cookie. It was fashionable among that group to fancy they were rather impersonal about dangers, risks, and human life. Helms would think it sentimental and foolish to be against something like this."
On April 13, 1953—the same day that the Pentagon announced that any U.S. prisoner refusing repatriation in Korea would be listed as a deserter and shot if caught—Allen Dulles approved the program, essentially as put forth by Helms. Dulles took note of the "ultra-sensitive work" involved and agreed that the project would be called MKULTRA.[2] He approved an initial budget of $300,000, exempted the program from normal CIA financial controls, and allowed TSS to start up research projects "without the signing of the usual contracts or other written agreements." Dulles ordered the Agency's bookkeepers to pay the costs blindly on the signatures of Sid Gottlieb and Willis Gibbons, a former U.S. Rubber executive who headed TSS.
As is so often the case in government, the activity that Allen Dulles approved with MKULTRA was already under way, even before he gave it a bureaucratic structure. Under the code name MKDELTA, the Clandestine Services had set up procedures the year before to govern the use of CBW products. (MKDELTA now became the operational side of MKULTRA.) Also in 1952, TSS had made an agreement with the Special Operations Division (SOD) of the Army's biological research center at Fort Detrick, Maryland whereby SOD would produce germ weapons for the CIA's use (with the program called MKNAOMI). Sid Gottlieb later testified that the purpose of these programs was "to investigate whether and how it was possible to modify an individual's behavior by covert means. The context in which this investigation was started was that of the height of the Cold War with the Korean War just winding down; with the CIA organizing its resources to liberate Eastern Europe by paramilitary means; and with the threat of Soviet aggression very real and tangible, as exemplified by the recent Berlin airlift" (which occurred in 1948).
In the early days of MKULTRA, the roughly six TSS professionals who worked on the program spent a good deal of their time considering the possibilities of LSD.[3] "The most fascinating thing about it," says one of them, "was that such minute quantities had such a terrific effect." Albert Hofmann had gone off into another world after swallowing less than 1/100,000 of an ounce. Scientists had known about the mind-altering qualities of drugs like mescaline since the late nineteenth century, but LSD was several thousand times more potent. Hashish had been around for millennia, but LSD was roughly a million times stronger (by weight). A two-suiter suitcase could hold enough LSD to turn on every man, woman, and child in the United States. "We thought about the possibility of putting some in a city water supply and having the citizens wander around in a more or less happy state, not terribly interested in defending themselves," recalls the TSS man. But incapacitating such large numbers of people fell to the Army Chemical Corps, which also tested LSD and even stronger hallucinogens. The CIA was concentrating on individuals. TSS officials understood that LSD distorted a person's sense of reality, and they felt compelled to learn whether it could alter someone's basic loyalties. Could the CIA make spies out of tripping Russians—or vice versa? In the early 1950s, when the Agency developed an almost desperate need to know more about LSD, almost no outside information existed on the subject. Sandoz had done some clinical studies, as had a few other places, including Boston Psychopathic, but the work generally had not moved much beyond the horse-and-buggy stage. The MKULTRA team had literally hundreds of questions about LSD's physiological, psychological, chemical, and social effects. Did it have any antidotes? What happened if it were combined with other drugs? Did it affect everyone the same way? What was the effect of doubling the dose? And so on.
TSS first sought answers from academic researchers, who, on the whole, gladly cooperated and let the Agency pick their brains. But CIA officials realized that no one would undertake a quick and systematic study of the drug unless the Agency itself paid the bill. Almost no government or private money was then available for what had been dubbed "experimental psychiatry." Sandoz wanted the drug tested, for its own commercial reasons, but beyond supplying it free to researchers, it would not assume the costs. The National Institutes of Mental Health had an interest in LSD's relationship to mental illness, but CIA officials wanted to know how the drug affected normal people, not sick ones. Only the military services, essentially for the same reasons as the CIA, were willing to sink much money into LSD, and the Agency men were not about to defer to them. They chose instead to take the lead—in effect to create a whole new field of research.
Suddenly there was a huge new market for grants in academia, as Sid Gottlieb and his aides began to fund LSD projects at prestigious institutions. The Agency's LSD pathfinders can be identified: Bob Hyde's group at Boston Psychopathic, Harold Abramson at Mt. Sinai Hospital and Columbia University in New York, Carl Pfeiffer at the University of Illinois Medical School, Harris Isbell of the NIMH-sponsored Addiction Research Center in Lexington, Kentucky, Louis Jolyon West at the University of Oklahoma, and Harold Hodge's group at the University of Rochester. The Agency disguised its involvement by passing the money through two conduits: the Josiah Macy, Jr. Foundation, a rich establishment institution which served as a cutout (intermediary) only for a year or two, and the Geschickter Fund for Medical Research, a Washington, D.C. family foundation, whose head, Dr. Charles Geschickter, provided the Agency with a variety of services for more than a decade. Reflexively, TSS officials felt they had to keep the CIA connection secret. They could only "assume," according to a 1955 study, that Soviet scientists understood the drug's "strategic importance" and were capable of making it themselves. They did not want to spur the Russians into starting their own LSD program or into devising countermeasures.
The CIA's secrecy was also clearly aimed at the folks back home. As a 1963 Inspector General's report stated, "Research in the manipulation of human behavior is considered by many authorities in medicine and related fields to be professionally unethical"; therefore, openness would put "in jeopardy" the reputations of the outside researchers. Moreover, the CIA Inspector General declared that disclosure of certain MKULTRA activities could result in "serious adverse reaction" among the American public.
At Boston Psychopathic, there were various levels of concealment. Only Bob Hyde and his boss, the hospital superintendent, knew officially that the CIA was funding the hospital's LSD program from 1952 on, to the tune of about $40,000 a year. Yet, according to another member of the Hyde group, Dr. DeShon, all senior staff understood where the money really came from. "We agreed not to discuss it," says DeShon. "I don't see any objection to this. We never gave it to anyone without his consent and without explaining it in detail." Hospital officials told the volunteer subjects something about the nature of the experiments but nothing about their origins or purpose. None of the subjects had any idea that the CIA was paying for the probing of their minds and would use the results for its own purposes; most of the staff was similarly ignorant.
Like Hyde, almost all the researchers tried LSD on themselves. Indeed, many believed they gained real insight into what it felt like to be mentally ill, useful knowledge for health professionals who spent their lives treating people supposedly sick in the head. Hyde set up a multidisciplinary program—virtually unheard of at the time—that brought together psychiatrists, psychologists, and physiologists. As subjects, they used each other, hospital patients, and volunteers—mostly students—from the Boston area. They worked through a long sequence of experiments that served to isolate variable after variable. Palming themselves off as foundation officials, the men from MKULTRA frequently visited to observe and suggest areas of future research. One Agency man, who himself tripped several times under Hyde's general supervision, remembers that he and his colleagues would pass on a nugget that another contractor like Harold Abramson had gleaned and ask Hyde to perform a follow-up test that might answer a question of interest to the Agency. Despite these tangents, the main body of research proceeded in a planned and orderly fashion. The researchers learned that while some subjects seemed to become schizophrenic, many others did not. Surprisingly, true schizophrenics showed little reaction at all to LSD, unless given massive doses. The Hyde group found out that the quality of a person's reaction was determined mainly by the person's basic personality structure (set) and the environment (setting) in which he or she took the drug. The subject's expectation of what would happen also played a major part. More than anything else, LSD tended to intensify the subject's existing characteristics—often to extremes. A little suspicion could grow into major paranoia, particularly in the company of people perceived as threatening.
Unbeknownst to his fellow researchers, the energetic Dr. Hyde also advised the CIA on using LSD in covert operations. A CIA officer who worked with him recalls: "The idea would be to give him the details of what had happened [with a case], and he would speculate. As a sharp M.D. in the old-school sense, he would look at things in ways that a lot of recent bright lights couldn't get.... He had a good sense of make-do." The Agency paid Hyde for his time as a consultant, and TSS officials eventually set aside a special MKULTRA subproject as Hyde's private funding mechanism. Hyde received funds from yet another MKULTRA subproject that TSS men created for him in 1954, so he could serve as a cutout for Agency purchases of rare chemicals. His first buy was to be $32,000 worth of corynanthine, a possible antidote to LSD, that would not be traced to the CIA.
Bob Hyde died in 1976 at the age of 66, widely hailed as a pacesetter in mental health. His medical and intelligence colleagues speak highly of him both personally and professionally. Like most of his generation, he apparently considered helping the CIA a patriotic duty. An Agency officer states that Hyde never raised doubts about his covert work. "He wouldn't moralize. He had a lot of trust in the people he was dealing with [from the CIA]. He had pretty well reached the conclusion that if they decided to do something [operationally], they had tried whatever else there was and were willing to risk it."
Most of the CIA's academic researchers published articles on their work in professional journals, but those long, scholarly reports often gave an incomplete picture of the research. In effect, the scientists would write openly about how LSD affects a patient's pulse rate, but they would tell only the CIA how the drug could be used to ruin that patient's marriage or memory. Those researchers who were aware of the Agency's sponsorship seldom published anything remotely connected to the instrumental and rather unpleasant questions the MKULTRA men posed for investigation. That was true of Hyde and of Harold Abramson, the New York allergist who became one of the first Johnny Appleseeds of LSD by giving it to a number of his distinguished colleagues. Abramson documented all sorts of experiments on topics like the effects of LSD on Siamese fighting fish and snails,[4] but he never wrote a word about one of his early LSD assignments from the Agency. In a 1953 document, Sid Gottlieb listed subjects he expected Abramson to investigate with the $85,000 the Agency was furnishing him. Gottlieb wanted "operationally pertinent materials along the following lines: a. Disturbance of Memory; b. Discrediting by Aberrant Behavior; c. Alteration of Sex Patterns; d. Eliciting of Information; e. Suggestibility; f. Creation of Dependence."
Dr. Harris Isbell, whose work the CIA funded through Navy cover with the approval of the Director of the National Institutes of Health, published his principal findings, but he did not mention how he obtained his subjects. As Director of the Addiction Research Center at the huge Federal drug hospital in Lexington, Kentucky, he had access to a literally captive population. Inmates heard on the grapevine that if they volunteered for Isbell's program, they would be rewarded either in the drug of their choice or in time off from their sentences. Most of the addicts chose drugs—usually heroin or morphine of a purity seldom seen on the street. The subjects signed an approval form, but they were not told the names of the experimental drugs or the probable effects. This mattered little, since the "volunteers" probably would have granted their informed consent to virtually anything to get hard drugs.
Given Isbell's almost unlimited supply of subjects, TSS officials used the Lexington facility as a place to make quick tests of promising but untried drugs and to perform specialized experiments they could not easily duplicate elsewhere. For instance, Isbell did one study for which it would have been impossible to attract student volunteers. He kept seven men on LSD for 77 straight days.[5] Such an experiment is as chilling as it is astonishing—both to lovers and haters of LSD. Nearly 20 years after Dr. Isbell's early work, counterculture journalist Hunter S. Thompson delighted and frightened his readers with accounts of drug binges lasting a few days, during which Thompson felt his brain boiling away in the sun, his nerves wrapping around enormous barbed wire forts, and his remaining faculties reduced to their reptilian antecedents. Even Thompson would shudder at the thought of 77 days straight on LSD, and it is doubtful he would joke about the idea. To Dr. Isbell, it was just another experiment. "I have had seven patients who have now been taking the drug for more than 42 days," he wrote in the middle of the test, which he called "the most amazing demonstration of drug tolerance I have ever seen." Isbell tried to "break through this tolerance" by giving triple and quadruple doses of LSD to the inmates.
Filled with intense curiosity, Isbell tried out a wide variety of unproven drugs on his subjects. Just as soon as a new batch of scopolamine, rivea seeds, or bufotenine arrived from the CIA or NIMH, he would start testing. His relish for the task occasionally shone through the dull scientific reports. "I will write you a letter as soon as I can get the stuff into a man or two," he informed his Agency contact.
No corresponding feeling shone through for the inmates, however. In his few recorded personal comments, he complained that his subjects tended to be afraid of the doctors and were not as open in describing their experiences as the experimenters would have wished. Although Isbell made an effort to "break through the barriers" with the subjects, who were nearly all black drug addicts, Isbell finally decided "in all probability, this type of behavior is to be expected with patients of this type." The subjects have long since scattered, and no one apparently has measured the aftereffects of the more extreme experiments on them.
One subject who could be found spent only a brief time with Dr. Isbell. Eddie Flowers was 19 years old and had been in Lexington for about a year when he signed up for Isbell's program. He lied about his age to get in, claiming he was 21. All he cared about was getting some drugs. He moved into the experimental wing of the hospital where the food was better and he could listen to music. He loved his heroin but knew nothing about drugs like LSD. One day he took something in a graham cracker. No one ever told him the name, but his description sounds like it made him trip—badly, to be sure. "It was the worst shit I ever had," he says. He hallucinated and suffered for 16 or 17 hours. "I was frightened. I wouldn't take it again." Still, Flowers earned enough "points" in the experiment to qualify for his "payoff in heroin. All he had to do was knock on a little window down the hall. This was the drug bank. The man in charge kept a list of the amount of the hard drug each inmate had in his account. Flowers just had to say how much he wanted to withdraw and note the method of payment. "If you wanted it in the vein, you got it there," recalls Flowers who now works in a Washington, D.C. drug rehabilitation center.
Dr. Isbell refuses all request for interviews. He did tell a Senate subcommittee in 1975 that he inherited the drug payoff system when he came to Lexington and that "it was the custom in those days.... The ethical codes were not so highly developed, and there was a great need to know in order to protect the public in assessing the potential use of narcotics.... I personally think we did a very excellent job."
For every Isbell, Hyde, or Abramson who did TSS contract work, there were dozens of others who simply served as casual CIA informants, some witting and some not. Each TSS project officer had a skull session with dozens of recognized experts several times a year. "That was the only way a tiny staff like Sid Gottlieb's could possibly keep on top of the burgeoning behavioral sciences," says an ex-CIA official. "There would be no way you could do it by library research or the Ph.D. dissertation approach." The TSS men always asked their contacts for the names of others they could talk to, and the contacts would pass them on to other interesting scientists.
In LSD research, TSS officers benefited from the energetic intelligence gathering of their contractors, particularly Harold Abramson. Abramson talked regularly to virtually everyone interested in the drug, including the few early researchers not funded by the Agency or the military, and he reported his findings to TSS. In addition, he served as reporting secretary of two conference series sponsored by the Agency's sometime conduit, the Macy Foundation. These series each lasted over five year periods in the 1950s; one dealt with "Problems of Consciousness" and the other with "Neuropharmacology." Held once a year in the genteel surroundings of the Princeton Inn, the Macy Foundation conferences brought together TSS's (and the military's) leading contractors, as part of a group of roughly 25 with the multidisciplinary background that TSS officials so loved. The participants came from all over the social sciences and included such luminaries as Margaret Mead and Jean Piaget. The topics discussed usually mirrored TSS's interests at the time, and the conferences served as a spawning ground for ideas that allowed researchers to engage in some healthy cross-fertilization.
Beyond the academic world, TSS looked to the pharmaceutical companies as another source on drugs—and for a continuing supply of new products to test. TSS's Ray Treichler handled the liaison function, and this secretive little man built up close relationships with many of the industry's key executives. He had a particular knack for convincing them he would not reveal their trade secrets. Sometimes claiming to be from the Army Chemical Corps and sometimes admitting his CIA connection, Treichler would ask for samples of drugs that were either highly poisonous, or, in the words of the onetime director of research of a large company, "caused hypertension, increased blood pressure, or led to other odd physiological activity."
Dealing with American drug companies posed no particular problems for TSS. Most cooperated in any way they could. But relations with Sandoz were more complicated. The giant Swiss firm had a monopoly on the Western world's production of LSD until 1953. Agency officials feared that Sandoz would somehow allow large quantities to reach the Russians. Since information on LSD's chemical structure and effects was publicly available from 1947 on, the Russians could have produced it any time they felt it worthwhile. Thus, the Agency's phobia about Sandoz seems rather irrational, but it unquestionably did exist.
On two occasions early in the Cold War, the entire CIA hierarchy went into a dither over reports that Sandoz might allow large amounts of LSD to reach Communist countries. In 1951 reports came in through military channels that the Russians had obtained some 50 million doses from Sandoz. Horrendous visions of what the Russians might do with such a stockpile circulated in the CIA, where officials did not find out the intelligence was false for several years. There was an even greater uproar in 1953 when more reports came in, again through military intelligence, that Sandoz wanted to sell the astounding quantity of 10 kilos (22 pounds) of LSD enough for about 100 million doses—on the open market.
A top-level coordinating committee which included CIA and Pentagon representatives unanimously recommended that the Agency put up $240,000 to buy it all. Allen Dulles gave his approval, and off went two CIA representatives to Switzerland, presumably with a black bag full of cash. They met with the president of Sandoz and other top executives. The Sandoz men stated that the company had never made anything approaching 10 kilos of LSD and that, in fact, since the discovery of the drug 10 years before, its total production had been only 40 grams (about 11/2 ounces).[6] The manufacturing process moved quite slowly at that time because Sandoz used real ergot, which could not be grown in large quantities. Nevertheless, Sandoz executives, being good Swiss businessmen, offered to supply the U.S. Government with 100 grams weekly for an indefinite period, if the Americans would pay a fair price. Twice the Sandoz president thanked the CIA men for being willing to take the nonexistent 10 kilos off the market. While he said the company now regretted it had ever discovered LSD in the first place, he promised that Sandoz would not let the drug fall into communist hands. The Sandoz president mentioned that various Americans had in the past made "covert and sideways" approaches to Sandoz to find out about LSD, and he agreed to keep the U.S. Government informed of all future production and shipping of the drug. He also agreed to pass on any intelligence about Eastern European interest in LSD. The Sandoz executives asked only that their arrangement with the CIA be kept "in the very strictest confidence."
All around the world, the CIA tried to stay on top of the LSD supply. Back home in Indianapolis, Eli Lilly & Company was even then working on a process to synthesize LSD. Agency officials felt uncomfortable having to rely on a foreign company for their supply, and in 1953 they asked Lilly executives to make them up a batch, which the company subsequently donated to the government. Then, in 1954, Lilly scored a major breakthrough when its researchers worked out a complicated 12- to 15-step process to manufacture first lysergic acid (the basic building block) and then LSD itself from chemicals available on the open market. Given a relatively sophisticated lab, a competent chemist could now make LSD without a supply of the hard-to-grow ergot fungus. Lilly officers confidentially informed the government of their triumph. They also held an unprecedented press conference to trumpet their synthesis of lysergic acid, but they did not publish for another five years their success with the closely related LSD.
TSS officials soon sent a memo to Allen Dulles, explaining that the Lilly discovery was important because the government henceforth could buy LSD in "tonnage quantities," which made it a potential chemical-warfare agent. The memo writer pointed out, however, that from the MKULTRA point of view, the discovery made no difference since TSS was working on ways to use the drug only in small-scale covert operations, and the Agency had no trouble getting the limited amounts it needed. But now the Army Chemical Corps and the Air Force could get their collective hands on enough LSD to turn on the world.
Sharing the drug with the Army here, setting up research programs there, keeping track of it everywhere, the CIA generally presided over the LSD scene during the 1950s. To be sure, the military services played a part and funded their own research programs.[7] So did the National Institutes of Health, to a lesser extent. Yet both the military services and the NIH allowed themselves to be co-opted by the CIA—as funding conduits and intelligence sources. The Food and Drug Administration also supplied the Agency with confidential information on drug testing. Of the Western world's two LSD manufacturers, one—Eli Lilly—gave its entire (small) supply to the CIA and the military. The other—Sandoz—informed Agency representatives every time it shipped the drug. If somehow the CIA missed anything with all these sources, the Agency still had its own network of scholar-spies, the most active of whom was Harold Abramson who kept it informed of all new developments in the LSD field. While the CIA may not have totally cornered the LSD market in the 1950s, it certainly had a good measure of control—the very power it sought over human behavior.

Sid Gottlieb and his colleagues at MKULTRA soaked up pools of information about LSD and other drugs from all outside sources, but they saved for themselves the research they really cared about: operational testing. Trained in both science and espionage, they believed they could bridge the huge gap between experimenting in the laboratory and using drugs to outsmart the enemy. Therefore the leaders of MKULTRA initiated their own series of drug experiments that paralleled and drew information from the external research. As practical men of action, unlimited by restrictive academic standards, they did not feel the need to keep their tests in strict scientific sequence. They wanted results now—not next year. If a drug showed promise, they felt no qualms about trying it out operationally before all the test results came in. As early as 1953, for instance, Sid Gottlieb went overseas with a supply of a hallucinogenic drug—almost certainly LSD. With unknown results, he arranged for it to be slipped to a speaker at a political rally, presumably to see if it would make a fool of him.
These were freewheeling days within the CIA—then a young agency whose bureaucratic arteries had not started to harden. The leaders of MKULTRA had high hopes for LSD. It appeared to be an awesome substance, whose advent, like the ancient discovery of fire, would bring out primitive responses of fear and worship in people. Only a speck of LSD could take a strongwilled man and turn his most basic perceptions into willowy shadows. Time, space, right, wrong, order, and the notion of what was possible all took on new faces. LSD was a frightening weapon, and it took a swashbuckling boldness for the leaders of MKULTRA to prepare for operational testing the way they first did: by taking it themselves. They tripped at the office. They tripped at safehouses, and sometimes they traveled to Boston to trip under Bob Hyde's penetrating gaze. Always they observed, questioned, and analyzed each other. LSD seemed to remove inhibitions, and they thought they could use it to find out what went on in the mind underneath all the outside acts and pretensions. If they could get at the inner self, they reasoned, they could better manipulate a person—or keep him from being manipulated.
The men from MKULTRA were trying LSD in the early 1950s—when Stalin lived and Joe McCarthy raged. It was a foreboding time, even for those not professionally responsible for doomsday poisons. Not surprisingly, Sid Gottlieb and colleagues who tried LSD did not think of the drug as something that might enhance creativity or cause transcendental experiences. Those notions would not come along for years. By and large, there was thought to be only one prevailing and hardheaded version of reality, which was "normal," and everything else was "crazy." An LSD trip made people temporarily crazy, which meant potentially vulnerable to the CIA men (and mentally ill, to the doctors). The CIA experimenters did not trip for the experience itself, or to get high, or to sample new realities. They were testing a weapon; for their purposes, they might as well have been in a ballistics lab.
Despite this prevailing attitude in the Agency, at least one MKULTRA pioneer recalls that his first trip expanded his conception of reality: "I was shaky at first, but then I just experienced it and had a high. I felt that everything was working right. I was like a locomotive going at top efficiency. Sure there was stress, but not in a debilitating way. It was like the stress of an engine pulling the longest train it's ever pulled." This CIA veteran describes seeing all the colors of the rainbow growing out of cracks in the sidewalk. He had always disliked cracks as signs of imperfection, but suddenly the cracks became natural stress lines that measured the vibrations of the universe. He saw people with blemished faces, which he had previously found slightly repulsive. "I had a change of values about faces," he says. "Hooked noses or crooked teeth would become beautiful for that person. Something had turned loose in me, and all I had done was shift my attitude. Reality hadn't changed, but I had. That was all the difference in the world between seeing something ugly and seeing truth and beauty."
At the end of this day of his first trip, the CIA man and his colleagues had an alcohol party to help come down. "I had a lump in my throat," he recalls wistfully. Although he had never done such a thing before, he wept in front of his coworkers. "I didn't want to leave it. I felt I would be going back to a place where I wouldn't be able to hold on to this kind of beauty. I felt very unhappy. The people who wrote the report on me said I had experienced depression, but they didn't understand why I felt so bad. They thought I had had a bad trip."
This CIA man says that others with his general personality tended to enjoy themselves on LSD, but that the stereotypical CIA operator (particularly the extreme counterintelligence type who mistrusts everyone and everything) usually had negative reactions. The drug simply exaggerated his paranoia. For these operators, the official notes, "dark evil things would begin to lurk around," and they would decide the experimenters were plotting against them.
The TSS team understood it would be next to impossible to allay the fears of this ever-vigilant, suspicious sort, although they might use LSD to disorient or generally confuse such a person. However, they toyed with the idea that LSD could be applied to better advantage on more trusting types. Could a clever foe "re-educate" such a person with a skillful application of LSD? Speculating on this question, the CIA official states that while under the influence of the drug, "you tend to have a more global view of things. I found it awfully hard when stoned to maintain the notion: I am a U.S. citizen—my country right or wrong.... You tend to have these good higher feelings. You are more open to the brotherhood-of-man idea and more susceptible to the seamy sides of your own society.... I think this is exactly what happened during the 1960s, but it didn't make people more communist. It just made them less inclined to identify with the U.S. They took a plague-on-both-your-houses position."
As to whether his former colleagues in TSS had the same perception of the LSD experience, the man replies, "I think everybody understood that if you had a good trip, you had a kind of above-it-all look into reality. What we subsequently found was that when you came down, you remembered the experience, but you didn't switch identities. You really didn't have that kind of feeling. You weren't as suspicious of people. You listened to them, but you also saw through them more easily and clearly. We decided that this wasn't the kind of thing that was going to make a guy into a turncoat to his own country. The more we worked with it, the less we became convinced this was what the communists were using for brainwashing."
The early LSD tests—both outside and inside the Agency—had gone well enough that the MKULTRA scientists moved forward to the next stage on the road to "field" use: They tried the drug out on people by surprise. This, after all, would be the way an operator would give—or get—the drug. First they decided to spring it on each other without warning. They agreed among themselves that a coworker might slip it to them at any time. (In what may be an apocryphal story, a TSS staff man says that one of his former colleagues always brought his own bottle of wine to office parties and carried it with him at all times.) Unwitting doses became an occupational hazard.
MKULTRA men usually took these unplanned trips in stride, but occasionally they turned nasty. Two TSS veterans tell the story of a coworker who drank some LSD-laced coffee during his morning break. Within an hour, states one veteran, "he sort of knew he had it, but he couldn't pull himself together. Sometimes you take it, and you start the process of maintaining your composure. But this grabbed him before he was aware, and it got away from him." Filled with fear, the CIA man fled the building that then housed TSS, located on the edge of the Mall near Washington's great monuments. Having lost sight of him, his colleagues searched frantically, but he managed to escape. The hallucinating Agency man worked his way across one of the Potomac bridges and apparently cut his last links with rationality. "He reported afterwards that every automobile that came by was a terrible monster with fantastic eyes, out to get him personally," says the veteran. "Each time a car passed, he would huddle down against the parapet, terribly frightened. It was a real horror trip for him. I mean, it was hours of agony. It was like a dream that never stops—with someone chasing you."
After about an hour and a half, the victim's coworkers found him on the Virginia side of the Potomac, crouched under a fountain, trembling. "It was awfully hard to persuade him that his friends were his friends at that point," recalls the colleague. "He was alone in the world, and everyone was hostile. He'd become a full-blown paranoid. If it had lasted for two weeks, we'd have plunked him in a mental hospital." Fortunately for him, the CIA man came down by the end of the day. This was not the first, last, or most tragic bad trip in the Agency's testing program.[8]
By late 1953, only six months after Allen Dulles had formally created MKULTRA, TSS officials were already well into the last stage of their research: systematic use of LSD on "outsiders" who had no idea they had received the drug. These victims simply felt their moorings slip away in the midst of an ordinary day, for no apparent reason, and no one really knew how they would react.
Sid Gottlieb was ready for the operational experiments. He considered LSD to be such a secret substance that he gave it a private code name ("serunim") by which he and his colleagues often referred to the drug, even behind the CIA's heavily guarded doors. In retrospect, it seems more than bizarre that CIA officials—men responsible for the nation's intelligence and alertness when the hot and cold wars against the communists were at their peak—would be sneaking LSD into each other's coffee cups and thereby subjecting themselves to the unknown frontiers of experimental drugs. But these side trips did not seem to change the sense of reality of Gottlieb or of high CIA officials, who took LSD on several occasions. The drug did not transform Gottlieb out of the mind set of a master scientist-spy, a protégé of Richard Helms in the CIA's inner circle. He never stopped milking his goats at 5:30 every morning.
The CIA leaders' early achievements with LSD were impressive. They had not invented the drug, but they had gotten in on the American ground floor and done nearly everything else. They were years ahead of the scientific literature—let alone the public—and spies win by being ahead. They had monopolized the supply of LSD and dominated the research by creating much of it themselves. They had used money and other blandishments to build a network of scientists and doctors whose work they could direct and turn to their own use. All that remained between them and major espionage successes was the performance of the drug in the field.
That, however, turned out to be a considerable stumbling block. LSD had an incredibly powerful effect on people, but not in ways the CIA could predict or control.

 

Notes

The description of Robert Hyde's first trip came from interviews with Dr. Milton Greenblatt, Dr. J. Herbert DeShon, and a talk by Max Rinkel at the 2nd Macy Conference on Neuropharmacology, pp. 235-36, edited by Harold A. Abramson, 1955: Madison Printing Company.
The descriptions of TSS and Sidney Gottlieb came from interviews with Ray Cline, John Stockwell, about 10 other ex-CIA officers, and other friends of Gottlieb.
Memos quoted on the early MKULTRA program include Memorandum from ADDP Helms to DCI Dulles, 4/3/53, Tab A, pp. 1-2 (quoted in Church Committee Report, Book I); APF A-1, April 13, 1953, Memorandum for Deputy Director (Administration, Subject: Project MKULTRA—Extremely Sensitive Research and Development Program; #A/B,I,64/6, 6 February 1952, Memorandum for the Record, Subject: Contract with [deleted] #A/B,I,64/29, undated, Memorandum for Technical Services Staff, Subject: Alcohol Antagonists and Accelerators, Research and Development Project. The Gottlieb quote is from Hearing before the Subcommittee on Health and Scientific Research of the Senate Committee on Human Resources, September 21, 1977, p. 206.
The background data on LSD came particularly from The Beyond Within: The LSD Story by Sidney Cohen (New York: Atheneum,1972). Other sources included Origins of Psychopharmacology: From CPZ to LSD by Anne E. Caldwell (Springfield, III.: Charles C. Thomas, 1970) and Document 352, "An OSI Study of the Strategic Medical Importance of LSD-25," 30 August 1955.
TSS's use of outside researchers came from interviews with four former TSSers. MKULTRA Subprojects 8, 10, 63, and 66 described Robert Hyde's work. Subprojects 7, 27, and 40 concerned Harold Abramson. Hodge's work was in subprojects 17 and 46. Carl Pfeiffer's Agency connection, along with Hyde's, Abramson's, and Isbell's, was laid out by Lyman B. Kirkpatrick, Memorandum for the Record, 1 December 1953, Subject: Conversation with Dr. Willis Gibbons of TSS re Olson Case (found at p. 1030, Kennedy Subcommittee 1975 Biomedical and Behavioral Research Hearings). Isbell's testing program was also described at those hearings, as it was in Document # 14, 24 July, 1953, Memo For: Liaison & Security Officer/TSS, Subject #71 An Account of the Chemical Division's Contacts in the National Institute of Health; Document #37, 14 July 1954, subject [deleted]; and Document # 41,31 August,1956, subject; trip to Lexington, Ky.,21-23 August 1956. Isbell's program was further described in a "Report on ADAMHA Involvement in LSD Research," found at p. 993 of 1975 Kennedy subcommittee hearings. The firsthand account of the actual testing came from an interview with Edward M. Flowers, Washington, D.C.
The section on TSS's noncontract informants came from interviews with TSS sources, reading the proceedings of the Macy Conferences on "Problems of Consciousness" and "Neuropharmacology," and interviews with several participants including Sidney Cohen, Humphrey Osmond, and Hudson Hoagland.
The material on CIA's relations with Sandoz and Eli Lilly came from Document #24, 16 November, 1953, Subject: ARTICHOKE Conference; Document #268, 23 October, 1953, Subject: Meeting in Director's Office at 1100 hours on 23 October with Mr. Wisner and [deleted]; Document # 316,6 January,1954, Subject: Lysergic Acid Diethylamide (LSD-25); and Document #338, 26 October 1954, Subject: Potential Large Scale Availability of LSD through newly discovered synthesis by [deleted]; interviews with Sandoz and Lilly former executives; interviews with TSS sources; and Sidney Gottlieb's testimony before Kennedy subcommittee, 1977, p. 203.
Henry Beecher's US government connections were detailed in his private papers, in a report on the Swiss-LSD death to the CIA at p. 396, Church Committee Report, Book I, and in interviews with two of his former associates.
The description of TSS's internal testing progression comes from interviews with former staff members. The short reference to Sid Gottlieb's arranging for LSD to be given a speaker at a political rally comes from Document #A/B, II, 26/8, 9 June 1954, Subject: MKULTRA. Henry Beecher's report to the CIA on the Swiss suicide is found at p. 396, Church Committee Report, Book I.

 

Footnotes

1. During the 1950s, Boston Psychopathic changed its name to Massachusetts Mental Health Center, the name it bears today. (back)
2. Pronounced M-K-ULTRA. The MK digraph simply identified it as a TSS project. As for the ULTRA part, it may have had its etymological roots in the most closely guarded Anglo-American World War II intelligence secret, the ULTRA program, which handled the cracking of German military codes. While good espionage tradecraft called for cryptonyms to have no special meaning, wartime experiences were still very much on the minds of men like Allen Dulles. (back)
3. By no means did TSS neglect other drugs. It looked at hundreds of others from cocaine to nicotine, with special emphasis on special-purpose substances. One 1952 memo talked about the urgent operational need for a chemical "producing general listlessness and lethargy." Another mentioned finding—as TSS later did—a potion to accelerate the effects of liquor, called an "alcohol extender." (back)
4. As happened to Albert Hofmann the first time, Abramson once unknowingly ingested some LSD, probably by swallowing water from his spiked snail tank. He started to feel bad, but with his wife's help, he finally pinpointed the cause. According to brain and dolphin expert John Lilly, who heard the story from Mrs. Abramson, Harold was greatly relieved that his discomfort was not grave. "Oh, it's nothing serious," he said. "It's just an LSD psychosis. I'll just go to bed and sleep it off." (back)
5. Army researchers, as usual running about five years behind the CIA, became interested in the sustained use of LSD as an interrogation device during 1961 field tests (called Operation THIRD CHANCE). The Army men tested the drug in Europe on nine foreigners and one American, a black soldier named James Thornwell, accused of stealing classified documents. While Thornwell was reacting to the drug under extremely stressful conditions, his captors threatened "to extend the state indefinitely, even to a permanent condition of insanity," according to an Army document. Thornwell is now suing the U.S. government for $30 million.
In one of those twists that Washington insiders take for granted and outsiders do not quite believe, Terry Lenzner, a partner of the same law firm seeking this huge sum for Thornwell, is the lawyer for Sid Gottlieb, the man who oversaw the 77-day trips at Lexington and even more dangerous LSD testing. (back)
6. A 1975 CIA document clears up the mystery of how the Agency's military sources could have made such a huge error in estimating Sandoz's LSD supply (and probably also explains the earlier inaccurate report that the Russians had bought 50,000,000 doses). What happened, according to the document, was that the U.S. military attaché in Switzerland did not know the difference between a milligram (1/1,000 of a gram) and a kilogram (1,000 grams). This mix-up threw all his calculations off by a factor of 1,000,000. (back)
7. Military security agencies supported the LSD work of such well-known researchers as Amedeo Marrazzi of the University of Minnesota and Missouri Institute of Psychiatry, Henry Beecher of Harvard and Massachusetts General Hospital, Charles Savage while he was at the Naval Medical Research Institute, James Dille of the University of Washington, Gerald Klee of the University of Maryland Medical School, Neil Burch of Baylor University (who performed later experiments for the CIA), and Paul Hoch and James Cattell of the New York State Psychiatric Institute, whose forced injections of a mescaline derivative led to the 1953 death of New York tennis professional Harold Blauer. (Dr. Cattell later told Army investigators, "We didn't know whether it was dog piss or what it was we were giving him.") (back)
8. TSS officials had long known that LSD could be quite dangerous. In 1952, Harvard Medical School's Henry Beecher who regularly gave the Agency information on his talks with European colleagues, reported that a Swiss doctor had suffered severe depression after taking the drug and had killed herself three weeks later. (back)

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